Yea ditto on disabling "Turn User Account Control on or off".
Mouse keybindings work fine, it's just that they don't show up properly in the keybindings UI. At least for me, when I bound a key to my mouse it would say the wrong mouse button, then if I bound another key it would replace my previous mouse binding even though it was a different mouse button. I could just save the bindings and they would work right, just don't show up right in the bindings UI /boggle.
I don't have problems with vent or anything in Vista64, but I have a pretty slimmed down list of services, turned off all but the things necessary for a gaming machine.
WAR:
Luroc the shaman, Hel Maor
Formerly:
Luroc the healer, Mid/Percival
Eethan the savage, Mid/Percival